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Anxiety & Stress

The "Physiological Sigh": Huberman's Favorite Stress Buster

What if you could reset your stress in under 60 seconds? Dr. Andrew Huberman, neuroscientist and professor at Stanford University, has popularized a simple breathing technique that does exactly that: the physiological sigh. This natural breathing pattern—which your body already uses unconsciously to reset stress—can be done intentionally for immediate relief from anxiety, tension, and overwhelm. Backed by groundbreaking research from Stanford, the physiological sigh is one of the fastest and most effective stress-busting techniques available. Discover how this simple exercise works, why it's so effective, and how to use it anytime you need a quick reset.

Last updated: January 2026Science-backed technique8-12 min read

What is the Physiological Sigh?

The physiological sigh is a natural breathing pattern that your body uses unconsciously to reset stress and restore calm. You've probably done it without realizing it—that deep, audible sigh you let out when you're stressed or overwhelmed. Dr. Andrew Huberman has popularized this technique as an intentional stress-busting tool, and research from his lab at Stanford University shows it's remarkably effective.

The physiological sigh involves taking two inhales followed by a long exhale. This pattern maximizes lung expansion and strongly activates the parasympathetic nervous system (the "rest and digest" response), providing immediate stress relief. Unlike many breathing techniques that require 5-10 minutes of practice, the physiological sigh works in under 60 seconds, making it perfect for quick stress resets throughout your day.

Key Insight:

The physiological sigh is your body's built-in stress reset mechanism. By doing it intentionally, you're simply activating a natural process your body already knows how to do. This is why it feels so natural and works so quickly—you're working with your body's existing stress management system, not against it.

How to Do the Physiological Sigh: Step-by-Step Guide

The physiological sigh is incredibly simple to learn and can be done anywhere, anytime. Here's the step-by-step technique:

The Physiological Sigh Technique

  1. Take a normal inhale through your nose. Don't force it—just a natural, comfortable breath in.
  2. Immediately take a second, slightly deeper inhale through your nose to fully fill your lungs. This second inhale should feel like you're "topping off" your lungs, maximizing their expansion.
  3. Exhale slowly and completely through your mouth (or nose if you need to be discreet) with an audible sigh. Let all the air out slowly, making a "whoosh" or sighing sound. The exhale should be longer than the combined inhales.
  4. Repeat 3-5 times for immediate stress relief. The entire process takes less than 60 seconds.

Quick Reference:

Pattern: Inhale → Inhale (deeper) → Exhale (long, with sigh) → Repeat 3-5 times

Duration: Less than 60 seconds for 3-5 cycles

When to use: Anytime you need quick stress relief—when anxiety strikes, before stressful situations, or during moments of tension

Tips for Best Results

  • Don't force it: The breaths should feel natural, not strained
  • Focus on the exhale: Make the exhale longer than the inhales
  • Let the sigh be audible: The sound helps release tension
  • Practice when calm first: Learn the technique when relaxed, then use it when stressed
  • Can be done discreetly: Use nose exhale if you need to be quiet

Common Mistakes to Avoid

  • Rushing the second inhale: Take your time with both inhales
  • Forcing the breath: Keep it natural and comfortable
  • Short exhale: Make sure the exhale is longer than the inhales
  • Doing too many cycles: 3-5 cycles is usually sufficient
  • Expecting instant results: Give it a few cycles to work

Why the Physiological Sigh Works: The Science

The physiological sigh is so effective because it works with your body's natural stress management systems. Understanding the science behind it helps you use it more effectively:

1. Maximizes Lung Expansion

The double inhale (normal breath + deeper breath) maximizes lung expansion, ensuring you're using the full capacity of your lungs. This increases oxygen intake and helps release any trapped air in the lower portions of your lungs. When your lungs are fully expanded, your body receives optimal oxygen, which helps reduce stress responses.

2. Strongly Activates the Parasympathetic Nervous System

The long, slow exhale is key to the physiological sigh's effectiveness. Extended exhales strongly activate the vagus nerve, which triggers the parasympathetic nervous system (the "rest and digest" response). This directly counteracts the sympathetic nervous system (fight-or-flight), slowing your heart rate, lowering blood pressure, and promoting calm. The longer the exhale relative to the inhale, the stronger the parasympathetic activation.

3. Releases Physical Tension

The audible sigh (the "whoosh" sound) isn't just for show—it helps release physical tension in your chest, shoulders, and diaphragm. When you sigh audibly, you're actively releasing built-up tension, which can provide immediate physical relief from stress. This physical release often leads to emotional relief as well.

4. Works with Your Body's Natural Systems

Your body already uses the physiological sigh unconsciously when you're stressed—you've probably noticed yourself sighing during tense moments. By doing it intentionally, you're simply activating a natural process your body already knows how to do. This is why it feels so natural and works so quickly—you're working with your body's existing stress management system.

5. Provides Immediate Feedback

Unlike some breathing techniques that take time to feel effects, the physiological sigh provides immediate feedback. You'll likely notice a sense of relief within the first cycle or two, which reinforces the practice and makes it easier to remember to use when you need it. This immediate feedback is part of what makes it so effective for quick stress resets.

The Research: What Science Says About the Physiological Sigh

The physiological sigh isn't just a wellness trend—it's backed by rigorous scientific research. Here's what the studies show:

Stanford University Study (2023)

A groundbreaking study published in Cell Reports Medicine by researchers at Stanford University (including Dr. Andrew Huberman's lab) compared different breathing techniques for stress relief. The study found that cyclic sighing (the physiological sigh) was more effective at reducing stress and improving mood than other breathing techniques, including meditation.

Study Details:

  • Participants practiced breathing exercises for 5 minutes daily for one month
  • Cyclic sighing (physiological sigh) group showed the greatest improvements
  • Significant reductions in stress, anxiety, and negative mood
  • Improvements were measurable within just one week
  • Effects were particularly strong for people with high baseline stress levels

Key Findings

  • • More effective than box breathing for stress relief
  • • More effective than meditation for mood improvement
  • • Works in under 60 seconds
  • • Safe for daily practice
  • • No special equipment or training needed

Why It's So Effective

Researchers believe the physiological sigh is so effective because it combines maximum lung expansion (double inhale) with strong parasympathetic activation (long exhale). This combination provides both immediate physical relief and nervous system reset, making it more effective than techniques that only address one aspect of stress.

When to Use the Physiological Sigh

The physiological sigh is perfect for quick stress resets throughout your day. Here are the best times to use it:

Anytime Stress Strikes

  • • When you feel anxiety or overwhelm
  • • During moments of tension or frustration
  • • When you notice shallow or rapid breathing
  • • Before or during stressful situations
  • • When you need a quick reset

Specific Situations

  • • Before important meetings or presentations
  • • During work breaks or transitions
  • • Before difficult conversations
  • • When feeling overwhelmed by tasks
  • • During moments of panic or anxiety spikes

Daily Practice

  • • Morning routine: 3-5 cycles to start your day calm
  • • Evening routine: 3-5 cycles to release daily stress
  • • Before bed: Helps prepare for restful sleep
  • • During meditation: Can enhance relaxation

As Part of a Routine

  • • Combine with other breathing exercises
  • • Use as a "reset" between tasks
  • • Practice after physical exercise
  • • Use during breathwork sessions

Pro Tip:

There's no limit to how often you can use the physiological sigh. It's safe to practice multiple times throughout the day whenever you need a quick reset. Many people find it helpful to do 3-5 cycles every hour or two during stressful periods, or whenever they notice tension building up.

Physiological Sigh vs. Other Breathing Techniques

The physiological sigh is excellent for quick stress relief, but how does it compare to other breathing techniques? Here's when to use each:

Physiological Sigh vs. Box Breathing

Physiological Sigh: Works in under 60 seconds, perfect for quick resets, easy to learn.Box Breathing: Better for longer practice sessions (5-10 minutes), provides steady calm, requires more focus. Use physiological sigh for immediate stress relief; use box breathing for longer practice sessions and building resilience.

Physiological Sigh vs. Coherent Breathing

Physiological Sigh: Quick reset (under 60 seconds), immediate relief.Coherent Breathing: Better for daily practice (5-10 minutes), builds long-term resilience, maximizes heart rate variability. Use physiological sigh for quick stress relief;use coherent breathing for daily practice and long-term stress management.

Physiological Sigh vs. 4-7-8 Breathing

Physiological Sigh: Works in under 60 seconds, can be done anywhere.4-7-8 Breathing: Better for sleep preparation, requires more time (2-5 minutes), deeper relaxation.Use physiological sigh for quick stress relief throughout the day; use 4-7-8 breathingfor sleep preparation and deeper relaxation.

Best Approach:

The physiological sigh works best as part of a comprehensive breathing practice. Use it for quick resets throughout your day, and combine it with longer practices like coherent breathing or box breathing for daily stress management. Think of the physiological sigh as your "emergency reset button" and other techniques as your "daily maintenance."

Tips for Effective Practice

Practice Tips

  • Learn when calm: Practice the technique when you're relaxed first
  • Focus on the exhale: Make the exhale longer than the inhales
  • Let it be audible: The sigh sound helps release tension
  • Don't force: Keep the breaths natural and comfortable
  • Practice regularly: Use it throughout your day, not just when stressed

Integration Tips

  • Set reminders: Use phone alarms to practice regularly
  • Anchor to activities: Practice before meals, during breaks, or between tasks
  • Combine with other techniques: Use as a quick reset during longer breathing practices
  • Notice the effects: Pay attention to how you feel before and after
  • Make it a habit: The more you use it, the more natural it becomes
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Practice the Physiological Sigh with Guided Support

Breathworkk provides guided physiological sigh exercises with visual cues and step-by-step instructions. Access this powerful stress-busting technique and other breathing exercises designed to help you manage stress and anxiety effectively.

Physiological Sigh Guides

Learn and practice the physiological sigh with guided sessions, visual cues, and step-by-step instructions that help you master this quick stress-busting technique.

Quick Reset Flows

Access quick stress relief sessions featuring the physiological sigh and other rapid-reset breathing techniques designed for immediate relief.

Frequently Asked Questions

What is the physiological sigh?

The physiological sigh is a breathing technique popularized by Dr. Andrew Huberman that involves taking two inhales followed by a long exhale. It's a natural breathing pattern your body uses to reset stress and can be done intentionally for immediate stress relief. Research from Stanford University shows this technique is highly effective for reducing anxiety and stress within 60 seconds.

How do you do the physiological sigh?

To do the physiological sigh: 1) Take a normal inhale through your nose, 2) Immediately take a second, slightly deeper inhale through your nose to fully fill your lungs, 3) Exhale slowly and completely through your mouth (or nose) with an audible sigh, 4) Repeat 3-5 times. This technique works in under 60 seconds and can be done anywhere.

Why does the physiological sigh work?

The physiological sigh works by maximizing lung expansion with the double inhale, which increases oxygen intake, and the long exhale strongly activates the parasympathetic nervous system (the "rest and digest" response). This combination quickly reduces heart rate, lowers stress hormones, and promotes calm. Research shows it can reduce anxiety and improve mood within 60 seconds.

How often should I practice the physiological sigh?

You can practice the physiological sigh anytime you need quick stress relief—when anxiety strikes, before stressful situations, or during moments of tension. For daily practice, do 3-5 cycles once or twice per day. There's no limit to how often you can use it—it's safe to practice multiple times throughout the day whenever you need a quick reset.

Is the physiological sigh better than other breathing exercises?

The physiological sigh is particularly effective for quick stress relief (works in under 60 seconds) and is easy to learn and practice anywhere. Other breathing exercises like box breathing and coherent breathing are better for longer practice sessions and building long-term stress resilience. The physiological sigh is best used as a quick reset tool, while other techniques are better for daily practice and deeper relaxation.

What does the research say about the physiological sigh?

Research from Stanford University published in Cell Reports Medicine found that the physiological sigh (cyclic sighing) was more effective at reducing stress and improving mood than other breathing techniques, including meditation. Participants who practiced cyclic sighing for 5 minutes daily showed significant improvements in stress, anxiety, and mood within just one week. The technique was found to be particularly effective for people with high baseline stress levels.